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That timing helps align the therapy with the moments of highest metabolic demand
It is important to note that although DPP-4 inhibition results in a systemic increase in active GLP-1 levels, recent animal data suggest that the glycaemic effects of DPP-4 inhibition might also involve local intestinal inhibition of DPP-4 activity, activation of incretin receptors, reduced liberation of bioactive peptides and increased vagus nerve activity [12]
These approaches do not replicate the pharmacologic effects of medications like Ozempic, but they can support insulin sensitivity, appetite regulation, and overall metabolic function
Current prescribing information advises discontinuing Wegovy immediately if pregnancy is recognized
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