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The risk of OA rises markedly with advancing age as joint structures deteriorate, and it is further amplified by prolonged exposure to risk factors such as prior joint injury and obesity (Steinmetz et al., 2023
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Apart from canonical necroptosis inhibitors, several natural products have been shown to suppress necroptosis in DKD models
Subsequent decades produced a steady stream of mechanism papers, animal wound healing studies, and small clinical trials
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