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Haemoglobin levels begin to rise after about one week, whilst the mean corpuscular volume (MCV), which is typically elevated in B12 deficiency, gradually normalises
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Additionally, the observation that changes in symptoms as assessed by PainDetect are correlated with changes in the CNFD in the ARA 290 treatment group alone, further support a functional relationship between small fiber density and neuropathic symptoms
Presented for research literature review only Cormier MJ et al
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