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Biochemistry 28 , 35623568 (1989)
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Diabetes 53:32673273 Sloop KW, Cao JX, Siesky AM et al (2004) Hepatic and glucagon-like peptide-1-mediated reversal of diabetes by glucagon receptor antisense oligonucleotide inhibitors
Moreover, although selective PDE1B and PDE10A inhibitors have demonstrated preclinical efficacy in ameliorating both positive and negative symptom-like behaviors, clinical translation has encountered challenges, including inadequate CNS penetration, dose-limiting toxicities, and variable target engagement
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