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Ann Med 36(6):42639
The risk of major osteoporotic fractures with GLP-1 receptor agonists when compared to DPP-4 inhibitors: a Danish nationwide cohort study
Indirect Systemic Effects Whether the cardiovascular benefits of GLP-1RAs depend on direct receptor activation in vascular and myocardial tissue or are mediated by indirect systemic effects on adipose-tissue inflammation, hepatic lipid handling, neurohumoral tone, and intestinal signaling remains incompletely resolved
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