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As pH-dependent dissociation of ligand-receptor complexes within acidic endosomes is known to influence post-endocytic receptor sorting (Borden et al., 1990), we wondered if the impact of low pH might specifically affect interactions made by the positively charged lixisenatide C-terminus, modulating intra-endosomal binding and thereby explaining its different recycling rate
Why pausing Ozempic is necessary To understand when you can restart Ozempic, it is essential to understand why it must be stopped in the first place
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