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FoxO activity is finely regulated by cofactors such as HDAC6, PGC-1, and GADD45, and by miRNAs including miR-182, miR-486, and miR-23

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doi: 10.3389/fimmu.2025.1699210 Received 05 September 2025 Revised 05 November 2025 Accepted 07 November 2025 Published 03 December 2025 Volume 16 - 2025 Edited by Stefan Tukaj, University of Gdansk, Poland Reviewed by Immadi Sudhakar Vamshidhar, All India Institute of Medical Sciences, India Alireza Arefzadeh, Islamic Azad University Central Tehran Branch, Iran Updates Copyright 2025 Murugan and Alzahrani

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Another clinical study clarified that adding RSV (100 mg/day, P.O for 2 months) better improved left ventricular ejection fraction and left ventricular diastolic function in patients with CHD compared with standard treatment alone [199]

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