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However, its poor solubility, rapid metabolism, and low bioavailability hinder clinical translation (Franciosoa et al
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Patients with these mutations may benefit from more personalized treatment strategies and close clinical monitoring to ensure optimal thyroid hormone replacement
Choline is also the precursor of the neurotransmitter ACh, whose synthesis is catalyzed by choline acetyltransferase (ChAT), transferring an acetyl group from acetyl-coenzyme A to choline, resulting in ACh and coenzyme A production ( Figure 2 )
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