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In the SURMOUNT-1 clinical trial , people taking tirzepatide lost between 15% and 20.9% of their body weight over 72 weeks, depending on dose, compared to just 3.1% in the placebo group
Excluding the trial judged at high risk of bias for efficacy outcomes likewise did not materially change the estimate (SMD 1.32, 95% CI 2.33 to 0.31
Some healthcare professionals may support a keto approach if it aligns with the patient's lifestyle and medical profile, whilst others may recommend more balanced dietary patterns with moderate carbohydrate intake
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