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study (1998) compared four topical treatments on human skin over one month, with immunohistological analysis of skin biopsies (actual tissue samples examined under a microscope)

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An enzyme called tyrosinase is needed to create melanin (the pigment that causes the brown spots) and while several other skin lightening agents work to inhibit the synthesis of tyrosinase itself (like vitamin C or licorice), arbutin lets tyrosinase be and rather hinders the melanin-forming activity of the enzyme

Super-concentrated 5,000 ppm L-glutathione tackles the look of discoloration, as licorice boosts brightening benefits, and allantoin visibly calms skin