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Cardiovascular safety has been specifically evaluated through thorough QT studies, which demonstrated no clinically relevant QTc prolongation, indicating no increased risk of ventricular arrhythmias
Allowing adequate rest and hydration reduces the intensity of the effect
This trial demonstrated that once-weekly administration of the highest dose of a unimolecular triple-agonist (GLP1RAGIPRAGCGRA) by subcutaneous injection in people with obesity and T2DM induces weight loss that appears comparable to that achieved with bariatric surgery, with a favourable safety and tolerability profile
The cagrilintide and semaglutide combination (CagriSema) is the flagship application, and the clinical data confirms that the combination produces greater weight loss than either compound alone
