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The organic layer was dried over anhydrous NaSO, filtered, and concentrated under reduced pressure to obtain Compound 2 (yield: 98%)
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In terms of the primary outcome of reduction in A1C from baseline, although the 3-mg oral semaglutide group did not demonstrate superiority to sitagliptin 100 mg at 26 weeks, the 7-mg and 14-mg dosage groups did demonstrate statistically significant reductions in A1C from baseline when compared with sitagliptin
Incretins A potential role for intestinal peptides in the treatment of type 2 diabetes (T2D) was based on the observation that insulin responses to an oral glucose load exceeded those after IV glucose administration measured at the same blood glucose concentration
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