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This creates a positive feedback loop: more fiber leads to more SCFA, which promotes more GLP-1, supporting blood sugar and appetite regulation (Mozafariun et al 2025
Xie Y, Choi T, Al-Aly Z
Metformin has a known GI effect that tends toward looser stools in some patients, which can partially offset GLP-1-related constipation
Current research is still ongoing and we are still learning exactly how this triple action translates into long term benefits and risks
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