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Proteobacteria are known as a microbial signature of disease (199) and one form, Enterobacteriaceae, is specifically increased in ME/CFS (191)

J Cell Sci 126:17131719 Lee SY, Lee SH, Yang EJ, Kim EK, Kim JK, Shin DY et al (2015) Metformin ameliorates inflammatory bowel disease by suppression of the STAT3 signaling pathway and regulation of the between Th17/Treg balance

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Of course, if the primary care physician only gets five to ten minutes to discuss them, then expecting the patient to become magically aware is unrealistic