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Graphical Abstract Similar content being viewed by others Introduction Professor Ernest Starling proposed the idea of using a gut hormone for the treatment of diabetes in London in the early 1900s and this idea was first tested by administering gut extracts to individuals with the disease [1]
Binding to GLP-1 Receptors It binds to GLP-1 receptors (GLP-1Rs), which are G-protein-coupled receptors found predominantly in pancreatic beta cells, as well as in alpha cells, the brain, and gastrointestinal tract
BMJ Open
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