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Retatrutide administered once weekly subcutaneously for 12 weeks resulted in a dose-dependent placebo-adjusted weight loss of up to 8.96 kg in the highest dose group and a placebo-adjusted HbA1c reduction of up to 1.6% in a phase II trial in individuals with T2DM [125]
In addition, analysis of the 5NCR has been reported not to discriminate well between HCV genotype 1 and genotype 6, subtypes c to l [28], [30], [31], [32]
9 There is a need for further longitudinal studies to confirm safety, which may slow adoption in broader patient populations
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