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This feature helps prevent abnormal activation of glycolysis under non-pathological conditions and preserves the dominant role of fatty acid oxidation in cardiac energy metabolism ( Within this metabolic framework, glucose metabolism operates in close coordination with fatty acid oxidation, mitochondrial function, and redox regulation
Shiimura et al., 2025)
This finding reinforces the concept that visceral and subcutaneous adipose tissues contribute differently to systemic inflammation, and that metabolic control plays a distinct role in disease pathophysiology (105, 106)
Heart Fail Rev 30 , 9911004 (2025)
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