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This section will systematically elaborate on the multi-dimensional mechanisms underlying immune inflammatory activation in the testicular microenvironment induced by varicocele, as well as the sequential pathological consequences and their regulatory networks, aiming to clarify the core role of immune inflammatory dysregulation in the pathogenesis of varicocele-related male infertility and lay a theoretical foundation for exploring targeted anti-inflammatory and microenvironment-regulating therapeutic strategies for this condition ( Figure 1 ) (12)

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