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Calcium overload triggers the activation of calcium-dependent enzymes, including calpains and caspases, which degrade cytoskeletal proteins and lead to neuronal death (Zhang and Bhavnani, 2006)
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The findings indicated that curcumin significantly reduced serum levels of estradiol ( p = 0.02), luteinizing hormone ( p = 0.009), testosterone ( p = 0.003), and the LH/FSH ratio ( p = 0.008) in PCOS rats
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