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Excessive fructose consumption stimulates liver lipogenesis, contributing to non-alcoholic fatty liver disease (NAFLD), a common comorbidity of T2D
OB GLP-1R stimulates insulin secretion by inhibiting sympathetic nervous system activity We next investigated the neurocircuitry underlying the observed effects on glycaemia, and hypothesised that the increase in insulin secretion during OGTT could be due to altered autonomic nervous system activity
Nature explains that, in trials, the drug has been found to reduce weight by an average of 24% over 48 weeks, making it a benchmark for weight-loss drugs
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