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Metabolism & Elimination GLP2 undergoes metabolism through pathways typical of peptide therapeutics: Plasma half-life of approximately 5 days in humans, enabling once-weekly administration Primary metabolic pathways include proteolytic cleavage of the peptide backbone, beta-oxidation of the C20 fatty diacid moiety, and amide hydrolysis Not metabolized via cytochrome P450 enzymes, sulfation, or glucuronidation pathways Low potential for drug-drug interactions mediated through hepatic metabolism or transporter systems The extended half-life represents a key pharmacokinetic advantage, with steady-state accumulation of approximately 1.7-fold enabling consistent therapeutic exposure throughout the dosing interval

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Groups in which it may be more relevant The relevance of carnitine may increase when dietary intake is low (for example, in strictly plant-based diets) or in clinical situations that alter homeostasis (e.g., renal disease with dialysis, certain medications)