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Timing considerations Injection timing affects both efficacy and side effects

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A 2018 review by Sikiric described its effects on the VEGF pathway, which drives the formation of new blood vessels (angiogenesis), and on the nitric oxide system, which regulates blood flow and inflammation

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Enterocolitis may occur several months after the last dose of ipilimumab and must be considered in cases not actively receiving this antibody [41]

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