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Table 2 summarizes RCTs of dual and triple GLP1-RA use in T2DM
The success of these medicines has spurred development of next-generation GLP-1-based drugs, promising greater weight loss, improved tolerability and additional options for the route and frequency of dosing
The first one is hyperglutamate theory, which accepts that glutamate levels are high in the serum and plasma of individuals with ASD, and the second one is the hypoglutamate theory, which states that there is dysfunction in glutamate receptors in ASD and glutamatergic agonists may have a positive effect on some of ASD symptoms [55]
In May 2024, Novo Nordisk announced plans to expand production capacity for Wegovy and Ozempic by investing over USD 4.1 billion in manufacturing facilities in Denmark and the U.S
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