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These events stimulate the secretion of insulin, helping to compensate for insulin resistance triggered by new-onset diabetes. The drug also suppresses glucagon release by the pancreas, resulting in glucose-dependent reduction in plasma glucose and postprandial glucose by inhibiting hepatic glucose production and delaying gastric emptying. GLP-1s also act in brain regions associated with appetite and reward, reducing food intake and promoting weight loss

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Other concerning symptoms include: Signs of dehydration (decreased urination, dizziness, extreme thirst) Persistent diarrhea lasting more than 48 hours Blood in stool or vomit Unexplained weight loss beyond expected therapeutic effects Severe constipation unresponsive to standard measures New or worsening heartburn or reflux symptoms Symptoms of gallbladder disease (right upper abdominal pain, especially after meals, fever, or jaundice) Signs of possible bowel obstruction or ileus (severe abdominal distension, inability to pass gas or stool) Before starting digestive enzyme supplements or any over-the-counter products, patients should discuss this decision with their healthcare provider or pharmacist

Many patients choose evening injections because they can observe any mild injection-site reactions while at home and before bed, when discomfort is less noticeable