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Extensive crosstalk exists between oxidative and ER stress as oxidative stress can disrupt redox homeostasis in the ER, triggering ER stress (95)
However, levels decline with age, illness, and environmental exposure
520 Subsequently, the study observed that treatment with liraglutide, both in vitro (cell culture models) and in vivo (mouse models), inhibited the tumor formation and metastatic capabilities of pancreatic cancer cells by activating GLP-1R
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