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Its unlikely that these pressures will ease, especially now that the Big Beautiful Bill Act (OBBBA) passed in July
IV and short-duration oral trials METAOD001-004 enrolled smaller groups of healthy or obese men with single doses or 1-week dosing across IV (25-400 mcg/kg) and oral (9-54 mg) routes
This enhanced stability allows more sustained receptor engagement in research settings
doi:10.1016/j.fertnstert.2026.06.002
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