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Russian preclinical literature is the main evidence base

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For example, a study on leukocytes (part of the immune system) shows that melatonin counteracts some of the effects of aging.[ref] Another study points out that foods that have been repeatedly shown to be protective against cardiovascular disease all contain melatonin.[ref] While I dont think melatonin is a silver bullet to prevent all aspects of aging, the bulk of the studies do show an overall anti-aging effect

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