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Supports immune cell production and responsiveness, helping maintain immune balance

The expected glucose-lowering efficacy is an important consideration when changing from one glucose-lowering agent to another or when adding a new agent to existing therapy

Orally Gastrointestinal discomfort, allergic reactions, worsening of asthma, toxicity, and interference with other medications

However, tirzepatide has 14 unique amino acids (engineered from the GIP sequence) and an amidated exenatide-like C terminus as opposed to GLP-1 which allow the peptide to possess a GIPR binding ability equivalent to GIP(142) and to steadily interact with GLP-1R with a reduced potency compared to GLP-1 23 (Fig