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Early Changes Often Occur Before Visible Weight Loss Many individuals notice changes in appetite and eating behaviour before significant changes are seen on the scale
This allows it to signal tissue growth even during training
The volume of reviews also matters
Option 4: combination approach The ATTAIN-MAINTAIN trial data suggests a compelling combination strategy: use injectable tirzepatide to achieve aggressive initial weight loss, then transition to oral orforglipron (once available) for convenient long-term maintenance
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