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We demonstrated that the GSH synthesis inhibitor buthionine sulfoximine (BSO) synergistically enhanced L-PAM activity (inducing 24 logs of cell kill) against nine MM cell lines (also in the presence of marrow stroma or cytokines) and in seven primary MM samples (combination indices 100 days, and significantly increased the median event-free survival relative to L-PAM alone
Even a nightstand in a room without air conditioning during summer months can push past the safe limit
It never even occurred to me that this was related to the copper until I started writing about it today
Touched on earlier, another key difference is multiple uses
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