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While direct cortisol measurements were not specifically reported in the published safety trials, the comprehensive metabolic monitoring across 900+ participants showed no clinically significant hormonal changes, and the mechanism of action provides no pathway for cortisol stimulation
The added acetyl group improves stability and makes it easier for the glutathione to enter cells thus boosting intracellular levels
These diverse mechanisms reduce the likelihood of resistance, enhancing therapeutic durability (Do et al., 2025)
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