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These hydroxylation reactions also require Fe 2+ as a cofactor, O 2 as a cosubstrate and ascorbic acid (vitamin C) as a reductase, which restore the activity of 2-OGDD enzymes (Fig
However, the concentrations found in food are often too low to significantly impact systemic antioxidant levels
In pregnancy : glutathione in the development of the fetus and placenta is crucial
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