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Patient safety, especially prevention of hypoglycemia, is paramount in insulin dose adjustments, but monitoring and education regarding side effects is a close second
Establishing that individuals carrying loss-of-function MC1R variants have reduced capacity to respond to endogenous -MSH or exogenous MC1R agonists
right upper quadrant pain should be evaluated promptly Hypoglycaemia : Particularly when combined with other diabetes medications Thyroid concerns : Animal studies showed thyroid C-cell tumours
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