Considering this feature, Asn240 is able to form hydrogen bonds with the conserved water molecule, the copper-coordinating His239, the backbone carbonyl group of Glu235 and the substrate (if it contains a functional group that is able to form H-bonds at its tail)
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Analyst 136(1):6466 Li G, Li X, Yang M, Chen M-M, Chen L-C, Xiong X-L (2013) A gold nanoparticles enhanced surface plasmon resonance immunosensor for highly sensitive detection of ischemia-modified albumin

Neurological symptoms are particularly significant and may include: Paraesthesia (pins and needles) in the hands and feet Numbness or altered sensation in the extremities Difficulty walking or problems with balance and coordination (ataxia) Memory problems and cognitive difficulties Mood changes, including depression and irritability Visual disturbances in severe cases Haematological and general symptoms commonly include: Pale or jaundiced (slightly yellow) skin Glossitis (sore, red, smooth tongue) Mouth ulcers and angular cheilitis (cracks at the corners of the mouth) Breathlessness, particularly on exertion Heart palpitations Headaches and dizziness Gastrointestinal symptoms may present as: Loss of appetite and unintentional weight loss Diarrhoea or constipation General digestive discomfort The severity and combination of symptoms vary considerably between individuals