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Since this study is a chart review as opposed to a clinical trial, it is difficult to apply these results to all patients with HS taking semaglutide

In rodent models, both GLP-1 and exendin-4 appear to influence reproductive efficiency via interaction with the hypothalamic kisspeptin (Kiss-1) system (Outeirino-Iglesias et al., 2015)

Another surprising effect that remains largely unexplained is that it actually Reverses testicular atrophy