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Withanolides are known to engage with GABAergic and serotonergic pathways, which mitigates the hyperactivation of the HPA axis, resulting in enhanced stress tolerance and anxiolytic effects (78)
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It also accelerates spinal cord injury recovery, resolving paralysis and enhancing nerve regeneration
GH peptides and MOTS-C are often discussed for this goal, but their mechanisms and separate studies are not proof of benefit during retatrutide treatment
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