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A patient suffering from severe, treatment-refractory hyperadrenergic POTSexperiencing debilitating tachycardia, tremors, and massive adrenaline surgeswas found to have a genetic polymorphism in their COMT pathway
It's already in the active state your body uses for methylation and DNA synthesis no extra conversion required
Untreated, severe deficiency can result in irreversible nerve damage
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