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With over 11 such drugs on the market as of early 2025, and more than 40 in the pipeline, their impact is positively seismic: patients can shed 15-20% of body weight in a year depending on BMI, one-to-two pounds per week often dramatically improving metabolic health and appearance
Lillys oral GLP-1 candidate, orforglipron, delivered a 12.4% average body weight reduction in a Phase 3 trial over 72 weeks
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