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selection should consider presence of cardiovascular disease, heart failure, or chronic kidney disease DPP-4 inhibitors (such as sitagliptin or linagliptin) oral agents with a different mechanism Insulin therapy particularly if glycaemic control is inadequate with oral agents Pioglitazone may be appropriate in selected patients without heart failure Sulfonylureas (such as gliclazide) though associated with hypoglycaemia and weight gain Your diabetes specialist or GP will conduct a comprehensive review of your treatment plan, considering factors such as HbA1c targets, cardiovascular risk profile, renal function, and personal preferences
doi: 10.1016/j.ecoenv.2020.110734, 81 Gonzlez-AbradeloD.Prez-LlanoY.Rodrguez-CamposJ.Navarro-NoyaY
Dose titration refers to the rate at which a patient gradually increases the amount of the medicine theyre taking, to mitigate potential side effects and give the body time to adjust
Mechanism: Collagen peptides provide building blocks for type II collagen synthesis and signal chondrocytes to produce more collagen and proteoglycans in cartilage matrix
