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While current redox proteomics in CF often focuses on identifying which proteins are modified (e.g., carbonylated, glutathionylated), techniques like FPOP offer the potential to delve deeper into how these modifications occur - identifying specific residues targeted by ROS - and how these modifications, or the oxidative environment itself, impact protein structure, dynamics, and interactions (Sun et al., 2025)
All these factors have a cascading effect and influence the regular cell cycle, whereby inhibition of apoptosis, reduced accumulation of anti-cancer drugs, and overexpression of oncogenes are common
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