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For instance, the active exclusion of Ca 2+ from the cytosol is impaired, 43 and the resulting increase in cytosolic Ca 2+ induces its uptake by mitochondria, leading to mitochondrial dysfunction and the opening of the mitochondrial permeability transition pore (MPTP)as a cause of cell death
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During states of chronic inflammation, zinc is rapidly depleted, leading to the degradation of ZO-1 and E-cadherin proteins
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