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BH4 Is Depleted By: Inflammation Oxidative stress (especially peroxynitrite) Poor folate conversion (via MTHFR and DHFR) Low NADPH or reduced glutathione In short
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Purine metabolites such as UA, inosine, and hypoxanthine are essential for maintaining redox balance and cellular energy homeostasis, with UA acting as a major endogenous antioxidant and other purines supporting ATP production
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