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TRIUMPH-4 Phase 3 data showed 28.7% mean weight loss (71.2 pounds) at 48 weeks, a result that, if replicated in registrational trials, would redefine the efficacy ceiling for the class

Tirzepatide causes weight loss through its action as a GLP-1 receptor agonist, which helps regulate appetite and reduce food intake

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In 2024 the Food and Drug Administration added cardiovascular risk as a reason to be prescribed the GLP-1 drug Wegovy, grounded in results from a major trial that showed fewer heart attacks, strokes, and cardiovascular deaths in adults with obesity or overweight and established heart disease