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The Gene Expression Paradox refers to the observation that BPC-157 is cleared from systemic circulation in approximately 15 minutes (mean elimination half-life in rats), yet its reparative effects persist for weeks
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It affects regulated BBB transport and receptor systems that are essential for normal BBB function, as well as decrease the functional activity of ion transporters ( + , K + , 2Cl cotransporter and Na + , K + -ATPase on BECs and inhibits P-gp activity in the CNS ( + /organic cation antiporter system is involved in blood-to-brain nicotine transport across BBB endothelial cells TR-BBB13 (Tega et al., 2018
Petrus, P
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