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About this article Cite this article Kunutsor, S.K., Seidu, S

Phenotypic screening is the pragmatic alternative: apply the peptide to a relevant cell system and measure broad outputs, transcriptome by RNA-seq, proteome, or metabolic and viability panels, without presupposing a target

The purinergic receptor family, including P2Y 12 (involved in microglial chemotaxis) and P2X 7 (which activates the inflammasome), is also being actively investigated as a potential pharmacological target [488, 489]

As a criterion for data inclusion, for a slope to be calculated for a peptide for an individual, at least three non-missing values were required for the peptide (out of four possible)