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Major functions of VIP include airway smooth muscle relaxation [112], stimulation of mucus secretion from airway glands and goblet cells [113], and vasodilation [112, 114]

Diabetes or metabolic syndromes: People living with diabetes or metabolic syndromes, such as high blood pressure, high blood sugar, excess body fat around the waist, and irregular cholesterol levels, may also experience inflammation in the body, which can impact the health of the shoulder and rotator cuff, particularly leading to adhesive capsulitis (frozen shoulder)

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People who follow a specific tirzepatide diet plan often find that timing their injection after their largest meal minimizes GI discomfort