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R471C has been shown to localise to the membrane and has ~15% activity of wildtype OCTN2 in CHO cells, which is consistent with the observed reduction in currents for R471A, meanwhile Y358N in CHO cells has ~8% activity, though localisation data for Y358N is unavailable 11,50
Furthermore, another recent evaluation demonstrated that Bedrocan with 22% THC, administered with the Syqe Inhaler to 27 patients with neuropathic pain/complex-regional pain syndrome, provided a statistically significant decline in pain intensity, measured fifteen minutes after the inhalation of 0.5 and 1.0 mg THC doses, and beyond [276]
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