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An optimized novel GLP-1-GIP receptor dual agonist with potent effects on body weight and glucose control in mice has the potential for once-weekly administration in humans
Clinical implications The diagnostic performance of thalamic GSH (AUC = 0.879) in this exploratory analysis suggests it warrants further investigation as a potential candidate diagnostic marker
10.1186/s13073-017-0451-z 36 BenakisC.BreaD.CaballeroS.FaracoG.MooreJ.MurphyM.et al
investigated the proximal signaling cascade and found that the mitochondrial phosphatase phosphoglycerate mutase family member 5 (PGAM5) is also involved in various pathways of regulated necrosis via interaction with another mitochondria-related protein dynamin-related protein 1 (Drp1) [213, 214]
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