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Among these metabolites, 52 were upregulated and 70 were downregulated in response to cystine treatment (Figures 2E,F)
L.GreinerJ
developed a novel hypoxia-activated combination nanomedicine that targets hypoxic tumors through hypoxia-sensitive block copolymers and photothermal/photodynamic therapy (PTT/PDT), efficiently delivering drugs and achieving synergistic anticancer effects of chemotherapy and PDT/PTT, completely eliminating advanced breast cancer, including hypoxic and metastatic tumors, stimulating a systemic antitumor immune response, and significantly improving survival rates, showing important clinical application potential [500]
Lincoff et al., 2023)
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