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Metabolic improvements from GLP-1 therapy may benefit breast cancer survivors, as obesity and insulin resistance are associated with poorer cancer outcomes
Dietary quality amplifies drug effects: GLP-1 receptor agonists reduce appetite and caloric intake, but the nutritional quality of consumed calories still matters for health outcomes
Current mainstay interventions, including intensive lifestyle modification and bariatric surgery, demonstrate suboptimal and often unsustainable long-term efficacy in this genetically defined population, highlighting a critical unmet need for effective, accessible, and durable pharmacological strategies
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